Hyaluronidase (human recombinant)
Hyaluronidase (human recombinant) is an enzyme pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| darzalex faspro | Biologic Licensing Application | 2024-08-08 |
| herceptin hylecta | Biologic Licensing Application | 2024-11-21 |
| hylenex recombinant | Biologic Licensing Application | 2024-01-24 |
| phesgo | Biologic Licensing Application | 2024-12-02 |
| vyvgart hytrulo | Biologic Licensing Application | 2024-08-14 |
Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
187 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 19 | — | 1 | 2 | — | 22 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | 1 | 3 | 8 | 1 | 3 | 13 |
| Primary immunodeficiency diseases | D000081207 | — | — | 1 | 3 | 8 | 1 | 3 | 13 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 3 | 5 | — | 2 | — | 10 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 3 | — | 3 | — | 8 |
| Dehydration | D003681 | — | E86.0 | 1 | — | — | 6 | 1 | 8 |
| Cardiac output | D002302 | — | — | — | — | — | 1 | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 11 | 6 | 5 | — | — | 20 |
| Plasma cell neoplasms | D054219 | — | — | 10 | 6 | 5 | — | — | 19 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 7 | 5 | — | 1 | 15 |
| Lymphoma | D008223 | — | C85.9 | 5 | 5 | 4 | — | — | 13 |
| Adenocarcinoma | D000230 | — | — | 4 | 4 | 2 | — | — | 8 |
| B-cell lymphoma | D016393 | — | — | 4 | 4 | 1 | — | — | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 3 | 2 | — | — | 7 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 2 | 2 | — | — | 5 |
| Melanoma | D008545 | — | — | — | 3 | 2 | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 3 | 1 | — | — | 5 |
Show 27 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 11 | 7 | — | — | — | 13 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 6 | 6 | — | — | — | 10 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 5 | 1 | — | — | — | 6 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | 1 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 2 | 1 | — | — | — | 3 |
| Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 3 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | 2 | — | — | — | 3 |
| Male breast neoplasms | D018567 | — | — | — | 3 | — | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | — | 2 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | — | — | — | — | 1 |
| Monocytic leukemia acute | D007948 | — | — | 1 | — | — | — | — | 1 |
| Castleman disease | D005871 | EFO_1001332 | D47.Z2 | 1 | — | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Sclerosis | D012598 | — | — | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Hypercholesterolemia | D006937 | — | — | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
| Stiff-person syndrome | D016750 | EFO_0007498 | G25.82 | — | — | — | — | 1 | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
| Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | — | — | — | — | 1 | 1 |
| Invasive hydatidiform mole | D002820 | — | D39.2 | — | — | — | — | 1 | 1 |
| Emergencies | D004630 | — | — | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hyaluronidase (human recombinant) |
| INN | vorhyaluronidase alfa |
| Description | Hyaluronidase (human recombinant) is an enzyme pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Enzyme |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201718 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 743QUY4VD8 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 1,505 documents
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Safety
Black-box Warning
Black-box warning for: Herceptin hylecta, Phesgo
Adverse Events
Top Adverse Reactions
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14,472 adverse events reported
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